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dc.contributor.authorBermingham ML
dc.contributor.authorBrotherstone S
dc.contributor.authorBerry DP
dc.contributor.authorMore SJ
dc.contributor.authorGood M
dc.contributor.authorCromie AR
dc.contributor.authorWhite IMS
dc.contributor.authorHiggins IM
dc.contributor.authorCoffey MP
dc.contributor.authorDowns SH
dc.contributor.authorGlass EJ
dc.contributor.authorBishop SC
dc.contributor.authorMitchell AP
dc.contributor.authorClifton-Hadley RS
dc.contributor.authorWoolliams JA
dc.contributor.editorBishop SC
dc.contributor.editorLunney JK
dc.contributor.editorPinard-van der Laan M-H
dc.contributor.editorGay CG
dc.identifier.citation5(Suppl 4):S1en_US
dc.description.abstractBackground: Here, we jointly summarise scientific evidence for genetic variation in resistance to infection with Mycobacterium bovis, the primary agent of bovine tuberculosis (TB), provided by two recent and separate studies of Holstein-Friesian dairy cow populations in Great Britain (GB) and Ireland. Methods: The studies quantified genetic variation within archived data from field and abattoir surveillance control programmes within each country. These data included results from the single intradermal comparative tuberculin test (SICTT), abattoir inspection for TB lesions and laboratory confirmation of disease status. Threshold animal models were used to estimate variance components for responsiveness to the SICTT and abattoir confirmed M. bovis infection. The link functions between the observed 0/1 scale and the liability scale were the complementary log-log in the GB, and logit link function in the Irish population. Results and discussion: The estimated heritability of susceptibility to TB, as judged by responsiveness to the SICTT, was 0.16 (0.012) and 0.14 (0.025) in the GB and Irish populations, respectively. For abattoir or laboratory confirmation of infection, estimates were 0.18 (0.044) and 0.18 (0.041) from the GB and the Irish populations, respectively. Conclusions: Estimates were all significantly different from zero and indicate that exploitable variation exists among GB and Irish Holstein Friesian dairy cows for resistance to TB. Epidemiological analysis suggests that factors such as variation in exposure or imperfect sensitivity and specificity would have resulted in underestimation of the true values.en_US
dc.publisherBioMed Centralen_US
dc.relation.ispartofProceedings of the International Symposium on Animal Genomics for Animal Health (AGAH 2010)en_US
dc.relation.ispartofseriesReport from the Second International Symposium on Animal Genomics for Animal Health: Critical Needs, Challenges and Potential Solutions
dc.titleEvidence for genetic variance in resistance to tuberculosis in Great Britain and Irish Holstein-Friesian populationsen_US
dc.title.alternativeInternational Symposium on Animal Genomics for Animal Health, Paris, Franceen_US

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